RAB11B - definitie. Wat is RAB11B
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Wat (wie) is RAB11B - definitie


RAB11B         
  • '''Alignment of inactive and active Rab11b (PDB-IDs: 2F9L/2F9M<ref name="Scapin SM, Carneiro FR, Alves AC, Medrano FJ, Guimarães BG, Zanchin NI 2006 260–8"/>).''' The alignment shows slight conformational differences between the GDP- and the GppNP-bound form. Major divergences are displayed in red. The Rab11b-GDP structure shows the α310 helix in the switch 2 region whereas Rab11b-GppNP does not. Rab11b-GDP model lacks in the switch 1 section 39–41. These amino acids could not be modeled from the electron density map. Due to the lack in switch 1 structure, the two states are not comparable from these models. Furthermore, the inactive state shows a truncated α-6 helix.
  • '''Cartoon model of active Rab11b-GppNP complex (PDB-ID: 2F9M<ref name="Scapin SM, Carneiro FR, Alves AC, Medrano FJ, Guimarães BG, Zanchin NI 2006 260–8"/>).''' This model includes amino acids 8–188. The model shows classic Ras-like structure with a six stranded beta sheet core encircled by 5 major and one minor α-helix. GppNp and Mg2+ form polar bonds with the residues S20, K24, S25, N27, S40/S42/T43 (switch1), N124, K125, D127, S154, and with some parts of the backbone highlighted in olive green. Hydrogen-bonds are drawn as black dots. Atoms of GppNP, Mg2+, and sidechains are colored corresponding to their element. O = red, N = blue, P = orange, and Mg = green. The purple sequence represents the Rab-typical α310 helix region.
PROTEIN-CODING GENE IN THE SPECIES HOMO SAPIENS
RAB11B (gene)
Ras-related protein Rab-11B is a protein that in humans is encoded by the RAB11B gene. Rab11b is reported as most abundantly expressed in brain, heart and testes.